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Online Interactive Course:

Evidence-based interventions to address nicotine, alcohol, and other substance use in primary care

Instructions: Complete all the modules then take the post-training survey to claim CME/CEU. Each module has 3-4 review questions. Answer each question correctly to advance in the module.

This course is presented for review purpose only.

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Evidence-based Screening for Substance Use in Primary Care
Screening for Substance Use
Introduction

Evidence-based Screening for Substance Use in Primary Care


Learning Objectives

  1. Describe the substance use continuum.
  2. Define standard drink and excessive drinking levels for healthy adults.
  3. List evidence-based screening tools for substance use.
  4. Discuss the workflow of substance use screening in the primary care setting.

Completion time: About 10 minutes

Substance Use Continuum

Substance Use Continuum

SU Continuum Spectrum

Substance use exists on a continuum of behavior. Universal screening of patients 12 and older allows us to know where our patients are at on that continuum, so that, depending on where they fall on that spectrum, we can reinforce abstinence or non-excessive use, intervene early before a SUD develops from excessive use, and provide patients with SUDs treatment or referral to treatment.


Most patients will screen as abstinent to all substances or non-excessive drinking. There is no non-excessive limit to nicotine or other substance use besides alcohol. The majority of patients screening positive in most primary care settings, roughly 25% of adult patients, will be at the excessive use level, i.e., they will not have a diagnosable SUD. Only a fraction of patients who screen positive will have a diagnosable SUD, roughly 5-10% of adult primary care patients, for which treatment is recommended.

The hallmarks of substance use disorders (SUD) are:

  • Continued use despite negative consequences
  • Loss of control over use
LevelUseConsequencesRepetitionLoss of control, preoccupation,
compulsivity, dependence
SUD Severe
SUD Mild/Moderaten/a
Excessive Usen/an/a
Abstinent/Non-Excessive Use✱ or n/an/an/an/a

CLICK HERE for the DSM-5 criteria for a formal SUD diagnosis.

Substance Use Disorders (SUDs) DSM-5

Substance Use Disorders (SUDs) DSM-5

  • Two to three of the following criteria for > 1 year = mild SUD
  • Four to five of the following criteria for > 1 year = moderate SUD
  • Six or more of the following criteria for > 1 year = severe SUD

Criteria
  • Role impairment (e.g. failed work or home obligations)
  • Hazardous use (e.g. driving while intoxicated)
  • Cravings for substance
  • Social or interpersonal problems due to substance
  • Tolerance
  • Withdrawal symptoms
  • Using the substance more than intended
  • Unsuccessful attempts to cut down
  • Excessive time related to substance (hangover, etc.)
  • Impaired social or work activities due to substance
  • Use despite physical or psychological consequences

Review Question

  1. Your patient is the 19yo daughter of a colleague who is seeing you ostensibly for a birth control visit, but your colleague shared their concerns about her marijuana use, which they think is continuing when she visits her boyfriend on weekends, and contributed to her slipping GPA and losing a merit-based scholarship at college this past semester.

    Where do you think this patient will screen on the substance use continuum?

    1. Non-excessive use/abstinence
    2. Excessive use
    3. Mild/Moderate Cannabis Use Disorder
    4. Severe Cannabis Use Disorder
Excessive Drinking Levels

Excessive drinking levels for healthy adults are defined as:

PersonsPer OccasionPer Week
Men (21+)> 4 drinks> 14 drinks
Women (21+)> 3 drinks> 7 drinks
Men (65+)> 1 drinks> 7 drinks
Pregnant> 0 drinks> 0 drinks
All < 21> 0 drinks> 0 drinks

The excessive drinking levels are based on counting Standard Drinks, defined as:

National Institute on Alcohol Abuse and Alcoholism / Alcohol's Effects on Health. [link]
12 oz. of beer or cooler 8-9 oz. of malt liquor 5 oz. of table wine 3-4 oz. of fortified wine (such as sherry or port) 2-3 oz. of cordial, liqueur or aperitif 1.5 oz. of brandy (a single jigger) 1.5 oz. of spirits (a single jigger of 80-proof)
beer malt wine fortified wine aperitif brandy spirits
12 oz.8.5 oz.5 oz.3.5 oz.2.5 oz.1.5 oz.1.5 oz.

Each standard drink listed across this chart contains the same amount of alcohol by weight.

That is, a 12 oz can of beer contains the same amount of alcohol as a 5 oz, (standard pour), glass of wine, which contains the same amount of alcohol as a single shot of 80 proof liquor or mixed drink made with a single shot.

As another comparison, a 6 pack of 12 oz beers has just a bit more alcohol than a bottle of wine which contains 5 standard-size servings.

A fifth of liquor is a fifth of a gallon (750 ml) and contains just over 25 ounces or 16 standard shots.

Review Question

  1. Your patient is a 54 yo male with a sports related injury, new to your practice. He is drinking 1 glass of wine with dinner nightly on weekdays, and two 40 oz beers after his soccer league games, on both Friday and Saturday evenings, with his teammates.

    His drinking:

    1. Exceeds daily and weekly limits
    2. Exceeds daily limits but not weekly limits
    3. Exceeds weekly limits but not daily limits
    4. Does not exceed excessive limits
Substance Use Screening Tools

These are commonly used, evidence-based SUD Screening Tools…

#: N=Nicotine/Tobacco, A=Alcohol, D=common Drugs of misuse
@: P=Patient self-administers, S=Staff or provider administers
*: Number of items varies as multiple questions per substance patient using
Screener NameSubstances#Number of itemsTime to administer (minutes)Administers@Additional Notes
ASSISTN,A,DMultiple*(2-8)10P and S (S scores)Built-in feedback, patient ed
AUDIT/
AUDIT-C
A only
A only
10
3
5
3
P or S
P or S
AUDIT-C for initial screen, full AUDIT if positive
CAGE/
CAGE-AID
A only
A and D
4
4
2
2
P or S
P or S
Doesn’t distinguish between lifetime/current problem
CRAFFT/
CRAFFT-N
A and D
N, A, D
4-9 items
5-10 items
2-5
2-5
P preferred
P preferred
Only validated screen for adolescents
DAST-10D only105P or SOften used with AUDIT
SQAS
SQDS
A only
D only
1
1
1
1
P or S
P or S
Rapid screens, distinguish excessive use and SUD
TAPS toolN, A, DMultiple* (4+)5-10P or S (auto scores)Derived from ASSIST, briefer, online tool

Click on a screener name for more information

ASSIST: Alcohol, Smoking and Substance Involvement Screening Test
Instrument

ASSIST Instrument

  • 8 questions asking about each substance patient endorses using
  • First 2 questions only, if patient never using any substances listed
  • Scores tallied per substance based on patient responses across the 8 questions

ASSIST instrument
Scoring

Score Interpretation

AlcoholAll other substances
Lower risk0-100-3
Moderate risk11-264-26
High risk27+27+

Risk level indicates need for intervention:
  • Lower risk = brief advice (health impacts of use)
  • Moderate risk = brief intervention
  • High risk = treatment or referral to treatment
Additional Notes

Additional Notes

  • Complex to administer and score: questionnaire, response card for patients, feedback report card for patients, risks of injecting card for patients
  • Developed by World Health Organization
  • Available in numerous languages
  • Cross-culturally validated
  • ASSIST instrument (V3.0) in English from www.who.int

Median sensitivity and specificity: 80% and 71%

AUDIT/AUDIT-C: Alcohol Use Disorders Identification Test
Instrument

AUDIT Instrument

AUDIT instrument
Scoring

Scoring

ASSIST instrument

Additional Notes

Additional Notes

  • Good for detecting current problem, poor at detecting past problem
  • Developed by World Health Organization
  • Available in numerous languages
  • AUDIT-C = first 3 questions only

Median sensitivity and specificity: 86% and 89%

CAGE / CAGE-AID: CAGE-Adapted to Include Drugs
Instruments
CAGE Instrument
  1. Have you ever felt you should CUT DOWN on your drinking?
  2. Have people ANNOYED you by criticizing your drinking?
  3. Have you ever felt bad or GUILTY about your drinking?
  4. Have you ever had a drink first thing in the morning to steady your nerves or get rid of a hangover (EYE OPENER)
CAGE-AID Instrument
  1. Have you ever felt you ought to CUT DOWN on your drinking or drug use?
  2. Have people ANNOYED you by criticizing your drinking or drug use?
  3. Have you felt bad or GUILTY about your drinking or drug use?
  4. Have you ever had a drink or used drugs first thing in the morning to steady your nerves or to get rid of a hangover (EYE OPENER)?
Scoring

Score Interpretation

CAGE/CAGE-AID Instruments:
One point for each “yes”; Positive screen = 2+ points

Additional Notes

Additional Notes

  • Not validated in adolescents, pregnant patients
  • No predictive value ranges for use disorders necessitating longer screening instruments or clinical assessment if positive
  • Does not assess excessive use
  • Cannot distinguish between past and current problem
  • Familiar to most health professionals and easy-to-recall acronym

CAGE - Sensitivity and specificity: 77% and 85%

CAGE-AID - Sensitivity and specificity: 79% and 77%


CAGE Source: Ewing 1984. CAGE-AID Source. Brown, R.L. and Rounds, LA Wisconsin Medical Journal 94: 135-140, 1995.

CRAFFT/CRAFFT-N (Nicotine)
Instrument

CRAFFT/CRAFFT-N Instrument

CRAFFT instrument
Scoring

Score Interpretation

CRAFFT Scoring bar graph
Additional Notes

Additional Notes

  • Only validated screen for adolescents
  • Screens explicitly for vaping
  • Easy-to-recall acronym

Sensitivity and specificity: 76% and 92% / 80%-94%


Knight JR et al. A new brief screen for adolescent substance abuse. Arch Pediatr Adolesc Med 1999;153(6):591-6
Knight JR et al. Validity of the CRAFFT substance abuse screening test among adolescent clinic patients. Arch Pediatr Adolesc Med 2002;156(6):607-14

DAST-10: Drug Abuse Screening TEST-10
Instrument

DAST-10 Instrument

These Questions Refer to the Past 12 Months

  1. Have you used drugs other than those required for medical reasons?
  2. Do you abuse more than one drug at a time?
  3. Are you unable to stop using drugs when you want to?
  4. Have you ever had blackouts or flashbacks as a result of drug use?
  5. Do you ever feel bad or guilty about your drug use?
  6. Does your spouse (or parents) ever complain about your involvement with drugs?
  7. Have you neglected your family because of your use of drugs?
  8. Have you engaged in illegal activities in order to obtain drugs?
  9. Have you ever experienced withdrawal symptoms (felt sick) when you stopped taking drugs?
  10. Have you had medical problems as a result of your drug use (e.g., memory loss, hepatitis, convulsions, bleeding)?
Scoring

Score Interpretation

Each “Yes” = 1 and each “No” = 0


Sum of “Yes” responses:
  • 0-1 No problem
  • 1-2 Excessive use
  • 3-5 SUD mild/moderate
  • 6+ SUD severe
Additional Notes

Additional Notes

  • Not well validated in women and cross-culturally
  • Doesn’t screen for alcohol
  • Stigmatizing language (abuse in Q2)

Sensitivity: 85%-91%, Specificity: 71%-73%


(Skinner, 1982)

SQAS/SQDS: Single Question Alcohol/Drug Screens
Instrument

SQAS/SQDS Instrument

  • SQAS: How many times in the last 12 months have you had x or more drinks in a day? ” (where x is 5 for men and 4 for women)
  • SQDS: How many times in the past year have you used an illegal drug or used a prescription medication for non-medical reasons (such as to get high)?)
Scoring

Score Interpretation

ScreenExcessive UseUse Disorder
SQAS1-78+
SQDS1-28+
Additional Notes

Additional Notes

  • Short to administer, score and interpret
  • Not as robust validation data for cutoffs or across populations as other instruments

Sensitivity / specificity: SQAS 88% / 84%, SQDS 97% / 99%


(Saitz et al, 2014)

TAPS Tool: Tobacco, Alcohol, Prescription medication and other Substance use
Instrument

TAPS-1 and TAPS-2 Instrument

  • TAPS-1: Four initial questions asking about each category of substance.

    For example, "In the PAST 12 MONTHS, how often have you used any prescription medications just for the feeling, more than prescribed or that were not prescribed for you?"

  • TAPS-2: Additional questions for each positive TAPS-1 question
Scoring

Score Interpretation

TAPS SCORERisk CategoryIntervention
0No Use in Past 3 MonthsReinforce Abstinence
1Problem UseBrief Intervention
2+Higher RiskTreatment or Referral to Treatment
Additional Notes

Additional Notes

  • For tobacco, alcohol, illicit drugs, lower for prescription drugs
  • Developed through NIDA (National Institute on Drug Abuse) which hosts online tool available for use by patient or staff/provider at www.drugabuse.gov/taps/#/
  • TAPS is available as an online tool that can be integrated into common EHR platforms

Sensitivity / specificity: [80%-90%] / [77%-92%]

Common Questions about Screening

What about urine drug screening (UDS)?
  • UDS and other biomarkers of use are a POOR SCREEN for SUDs.
  • Gives information about use vs non-use at one specific point in time, whereas SUDs are about patterns of use and consequences of use over time.
  • Useful for nonverbal patients, emergent/tox syndromes, but typically must make and act on clinical decisions before results available.
  • Great tool for confirming, monitoring, and accountability during SUD treatment.
  • Random, observed, chain of custody of specimen issues should be addressed.
  • Know lab cutoffs for various substances as well as common cross reacting medications and herbals/supplements, i.e., false positives.
  • Privacy issues, multiple ways to tamper.
How accurate is self report?
Is self report really reliable?
  • Interview is usually the most accurate source of information about a patient’s substance use.
  • Accurate assessment is achievable even with minimization.
  • All the evidence-based screening tools have been validated in real world clinical settings.
  • Appropriate assessment techniques that avoid stigmatizing substance use can build rapport and increase the accuracy of the assessment.

Review Question

  1. In screening the 19 yo patient who is your colleague’s daughter for substance use, you select which of the following screening tools as it is validated for use in adolescence and screens for all substances:

    1. ASSIST
    2. CRAFFT+N
    3. DAST
    4. Urine Drug Screen
3 Steps of Substance Use Screening

Substance use screening involves 3 steps

1

Setting the stage:

  • Non-pregnant adults: Normalize
  • Pregnant adults: Address Stigma
  • Children and Teens: Address Confidentiality
2

Using evidence-based screen:

  • Adults: Single Questions (Nicotine use, SQAS, SQDS), AUDIT -C -3(US), ASSIST, DAST
  • Adolescents (12 to 21yo): Single Question then CRAFFT
3

Providing feedback:

  • Abstinence or low risk: Reinforce healthy choices
  • At risk or use disorder: Express concern, link risk to current health/risky drinking limits and seek patient’s perspective and their permission to discuss more

Let’s explore more

1

Setting the stage for screening:

Scripts can help...


Non-pregnant adult:
Normalize

“Substance use can affect health, so I ask all my patients yearly about their use of nicotine, alcohol and other drugs.”


Pregnant adult:
Address stigma

“My pregnant patients often have questions or concerns about using nicotine, alcohol or other substances during pregnancy or before realizing they were pregnant. How about you?”


Adolescent:
Confidentiality

Speaking with patient alone: “Use of nicotine, alcohol, marijuana and other drugs, if any, during adolescence can affect health and development. What you tell me about that is confidential unless it would endanger yourself or someone else. Do you have any questions about that?”

2

Use Evidence-Based Screens, such as:

Do you smoke or use other nicotine products?

Age 12-17: How many times in the past 12 months did you drink any alcohol (> a few sips)?

Adults: How many times in the past 12 months have you had more than [4(men), 3(women)] drinks in one day?

SQAS
Adolescent and Adult

How many times in the past year have you used an illegal drug or used a prescription medication for non-medical reasons (like to get high)?

SQDS

3

Give targeted feedback that’s brief and relevant to the patient’s level of use


Abstinent/Non-excessive Use:
  • Reinforce healthy choices and leave door open

    “You are making healthy decisions about substance use. Let me know if you have any questions about substance use and health or concerns about a loved one’s substance use.“

Excessive Use/SUD mild/moderate/SUD severe:
  • Express concern, connect substance use to patient’s health (when possible) and seek patient perspective

    “I’m concerned about how your drinking/smoking/using may be affecting your blood pressure control. What are your thoughts about that?”

  • Share excessive drinking limits, if applicable, and seek patient perspective

    “For women, the healthy limit is no more than 3 drinks in one day and it sounds like sometimes you are drinking a bit more than that. What do you think about that?”

  • Ask permission to continue discussion (transition to Brief Intervention)

    “Is it alright if we talk a little more about your opioid use?”

Review Question

  1. You are training your staff in the practice's new SBIRT workflow. Your SBIRT champion implementation team has determined, given your patient population's overall discomfort with completing electronic and paper forms, that the medical assistants will administer the evidence-based screening instrument verbally as they are rooming the patients and enter the results into the EHR for the provider to review.

    One of the medical assistants expresses concern that asking patients about their substance use may offend them.

    Which of the statements below is an example of normalizing communication when setting the stage for screening?

    1. “These are interview questions that we ask patients with certain risk factors for nicotine, alcohol and other drugs use.”
    2. “Do you use nicotine, alcohol or other drugs regularly?”
    3. "Because of the reason for your visit today, I need to ask a few routine questions about your lifestyle that I ask patients like you.“
    4. “We ask all our patients about their nicotine, alcohol and other drugs use as part of their medical history because it can have an important impact on overall health."

This is one example of a screening protocol integrated into the clinical setting...

Brief Interventions to Address Substance Use in Primary Care
Brief Interventions
Introduction

Brief Interventions to Address Substance Use in Primary Care


Learning Objectives

  1. Explain the Transtheoretical Model (TTM) (or Stages of Change).
  2. Discuss key principles and practices of Motivational Interviewing (MI).
  3. Apply the TTM and MI in conducting brief interventions to address substance use.

Completion time: About 10 minutes

Transtheoretical Model (TTM)

Brief Interventions: Stages of Change

Spiral of Change

The Transtheoretical Model (TTM), first described in 1984 by Prochaska and DiClemente, recognizes change as a non-linear process involving several stages leading to successful behavior change.


StageCharacteristic
Pre-contemplationNo intention to change. Unaware of problem or possibility of successful change
ContemplationAware of the problem & considering a change, but no commitment to take action
PreparationIntent to change and making small behavioral modifications toward change
ActionTaking decisive action to change
MaintenanceWorking to prevent relapse and consolidate gains

Brief Interventions: Facilitating change

Diagram-TTM

The primary goal of the brief intervention is to positively facilitate the patient’s movement between the stages of change, helping them progress through the stages and avoid relapse.

Brief Interventions: Goal by Stage

Brief interventions can be most effective when the goals of the intervention are tailored to the patient’s current stage of change.


Diagram-Goal by Stage

Patients screening positive for substance use are likely to be in pre-contemplation or contemplation. They haven’t yet considered their substance use to be a problem or have been thinking about change but have not yet decided on following through with making the considered change.

Review Question

  1. Your next patient is 43 yo and new to your practice coming in for back pain. They work as a landscaper and have been taking opioids as prescribed by their previous primary care physician for the last 10 years. Their previous physician recently retired.

    On their substance use screen today, the patient screens positive for prescription opioid misuse, having resorted to buying hydrocodone pills off a co-worker whose mother recently passed from cancer, and taking more than previously prescribed doses.

    You share the patient’s screening results with them while discussing their medical history and ask the patient their thoughts on their opioid use. The patient states “I don’t see there is any problem except my old doc retired, but now you’re my new doc and that should fix that problem.”

    The patient’s current stage of change with regards to their opioid use is most likely:

    1. Pre-contemplation
    2. Contemplation
    3. Preparation
    4. Action
Motivational Interviewing (MI)

Brief Interventions: Motivational Interviewing

“Motivational Interviewing is a collaborative conversation style for strengthening a person’s own motivation and commitment to change.”

– Miller and Rollnick, 2012

Photo of doctor listening to patient

In a Brief Intervention, the clinician applies MI Principles using OARS Skills with MI SPIRIT to elicit change talk while showing compassion and curiosity about a patient’s process of change.

Click on the 4 underlined terms above for more information

MI Principles
1. Express Empathy

Expressing empathy conveys acceptance of the patient for who they are and what stage of change they are in. Acceptance facilitates change and recognizes ambivalence as a normal part of the change process. Reflective listening is a fundamental skill for expressing empathy.

A primary goal of this principle is to build rapport.


2. Develop Discrepancy

Change is motivated by a discrepancy between a patient’s perceived goals and values versus their current behavior. The clinician should elicit the patient’s own reasons for behavior change rather than provide the patient with external reasons for making a change.

A primary goal of this principle is to raise and/or heighten ambivalence.


3. Roll with Resistance

By rolling with resistance, the clinician avoids argumentation and persuasion, which often leads to resistance to change. The patient shares their own perspectives on the change process, providing answers and solutions. Resistance is taken as signal by the clinician to respond differently.

A primary goal of this principle is to respect patient autonomy.


4. Support Self-Efficacy

The patient’s belief in their capacity and capability to change is a key motivator. Behavior change is the patient’s responsibility. The clinician affirms the patient’s responsibility and internal resources for change.

A primary goal of this principle is to affirm the patient’s capability for change.


The OARS Skills of MI
OARS

OARS is an acronym for the 4 key conversational skills used in MI

  • O Open-ended questions
  • A Affirmations
  • R Reflective listening
  • S Summarizing
Open-ended questions

Open ended questions allow patients to express their own views and the physician to follow patients’ perspectives. An open-ended question cannot be answered with ‘yes’, ‘no’ or other single word response.


“What problems have you experienced as a result of your smoking?”

Affirmations

Actively listen for patient strengths, values, aspirations, positive qualities and reflect those to the patient in an affirming manner.


“You were able to meet your fitness goal despite the pandemic because of your perseverance and determination. Those strengths can help you cut back on your drinking.”

Reflective listening

Reflective listening mirrors what a patient says in non-threatening manner, using the patient’s own word choices and phrasing when possible, to deepen the conversation. Reflective listening lets the patient know you are hearing them and seeking to understand their perspective. It is collaborative and nonjudgmental. Reflecting back change talk statements helps patients better connect with and understand their own motivations for change and resolve ambivalence.


(Patient: I’d stop using if I could afford treatment and didn’t have to miss work because of it.) “You’d stop using pain pills if there was an affordable, outpatient treatment option.”

Summarizing

Summaries are collections of change talk reflections that are used to highlight realizations, identify progress or themes, and manage transitions in the conversation. Ending a brief intervention with a strategic, collaborative summary reinforces the patient’s motivation for change.


“So we’ve talked today about your vaping and how while you find it relaxing and thought when you switched that it was less harmful than smoking, you’re worried now about it increasing your risk during the pandemic and its increasing cost.”

MI Spirit

The Spirit of MI: PACE

MI strives for…
  • Partnership: clinician respects and affirms patient’s right and capacity for self-direction
  • Acceptance: clinician accepts the patient’s values and life goals
  • Compassion: clinician appreciates change as a process, stage of change not fixed, meets patient where they are at
  • Evocation: clinician evokes patient’s own motivations/ resources for change

MI avoids…
  • Paternalism: clinician prescribes need and plan for change
  • Authority: clinician decides on values and goals that should be important to patient
  • Confrontation: clinician confronts patient on need for behavior change, assuming lack of motivation to change is a fixed state or patient characteristic
  • Education: clinician presumes patient lacks knowledge to successfully change, provides unsolicited education/advice
Change Talk

Change Talk: fuel for change ‘DARN CATs”

Hearing one’s own reasons for change is a powerful motivator. Using open-ended questions is a great way to elicit change talk.

Listen for the following phrases to recognize change talk for reflecting back and summarizing to the patient.


Preparatory Change Talk
(Pre-contemplation / Contemplation)
  • Desire: ”I want to…”
  • Ability: “I can…”
  • Reasons: “Because…”
  • Need: “I need to…”

Mobilizing Change Talk
(Preparation/Action)
  • Commitment: “I do…”
  • Actuation: “I’m ready to…”
  • Taking steps: Discusses ongoing work toward change

Review Question

  1. You are seeing a well-established, 68yo patient for follow up of their COPD after a recent hospitalization for COVID-19. He is thankful to have made it through a lengthy hospital stay and is embarrassed to disclose that he started smoking again soon after returning home but wants help to quit and stay quit:

    “I don’t ever want to feel like I can’t breathe like that again. That was a really close call. I’ve got my third grandchild on the way and the rest of my retirement to enjoy.”

    He doesn’t remember getting any medication or a nicotine replacement product while hospitalized but didn’t notice cravings or withdrawal then either, probably because “I was too sick to notice much of anything”. His cravings returned on the car ride home, when he noticed a half-smoked pack in the center console. Other than that, he doesn’t know why he resumed smoking as he feels ”tired and done with that” and gets more anxious than relaxed when he smokes now.

    In the past he has tried various nicotine replacement products including patches, gum and lozenges. His longest time quit was 1 year, after the birth of his first grandchild, which motivated that quit attempt. He is smoking half a pack a day now, down from 1 pack a day.

    Which of the following is a MI congruent statement you could make that would further support this patient’s efforts to quit smoking?

    1. “Smoking is not relaxing anymore, and you are worried if you don’t quit smoking you won’t get to enjoy your retirement or see your grandchildren grow up. You’re ready to quit.”
    2. “You’ve been successful quitting for a full year before. I’m confident you can do this.”
    3. “What do you think would help you quit and stay quit this time?”
    4. All of the above
3 Steps of Brief Interventions

3 Steps of Brief Interventions

1

Decisional Balance to open discussion and explore ambivalence

2

Readiness Ruler to identify stage of change

3

Brief Discussion targeting stage of change to elicit change talk:

  • Pre-contemplative: ask about negative consequences, respect autonomy, offer follow up
  • Contemplative: reflect lower/higher on readiness ruler, explore “what if” plan, offer follow up
  • Preparation/Action: affirm decision to change, develop plan, identify resources and offer follow up

Let’s explore more.

3 Steps of Brief Interventions

1

Decisional Balance to open discussion and explore ambivalence

START with

“So what do you like about [current behavior]___?”

THEN

“What do you dislike about [current behavior]___?”

END with

Summary of pros and cons:

  • Use patient’s own words to reflect back what they said
  • Start with their pros, end with their cons
  • Do not add your own cons

“You like that the opioids take away your pain, and you dislike that sometimes they make you too sleepy to function and it’s causing a lot of stress in your marriage.”

3 Steps of Brief Interventions

2

Readiness Ruler to identify stage of change

“So where does that leave you: on a scale of 0 to 10, where 0 is not at all ready and 10 is you’re ready to change today, how ready are you to [make behavior change]?”


Image of scale 0-10
ScoreReadinessStage of ChangeFocus of Intervention
0-3Not ReadyPre-ContemplationEngage: raise awareness of problem
4-7AmbivalentContemplationExplore: heighten discrepancy
8-10ReadyPreparation / ActionPlan for change / Sustain change

3 Steps of Brief Interventions

3

Brief Discussion targeting stage of change to elicit change talk

Pre-Contemplation

Readiness Scores 0-3

Elicit patient’s perceived negative consequences

What’s happened as a result of your drinking that you later regretted?

I forgot it was my turn to drive for carpool last week and that was embarrassing.

Express concern

You were embarrassed by that. I am concerned that your drinking may be contributing to your anxiety rather than helping it.

Offer information

Would you like more information about how alcohol may be impacting your health?

No, I don’t have time to talk about this now. It's really not a big deal anyways.

Support and follow-up

I respect that you aren’t ready to talk about your drinking more right now. Thanks for sharing what you have today. I will plan to ask you about it at our next appointment if that’s ok.

Contemplation

Readiness Scores 4-7

Explore motivation to change

Why a [patient-stated number] and not a [lower number]?

I really shouldn’t forget to do things – I hate it when I do that. So maybe I should slow down some.

What would have to happen for you to go from a [patient-stated number] to a [higher number]?

I guess if it became a problem with work, I mean besides the carpool.

So you don’t like forgetting things and you’d definitely make a change if your drinking started interfering with work.

Explore a tentative change plan for when patient is ready and offer follow up

With that in mind, what do you think a change would look like when you are ready to cut back or stop?

I think I could work on not drinking during the week. Maybe stick to the weekends only.

That sounds like a good idea. How would you feel about me checking in with you about this the next time we see each other?

That sounds fine to me.

Preparation-Action

Readiness Scores 8-10

Affirm patient’s decision to change

You’re ready to make this change. That’s a great decision for your health

I really am ready to cut back – I don’t want to live this way anymore. I’m tired of it.

Help patient develop action plan

Let’s identify the steps you can take to help you cut back. What do you see as a first step?

I guess I could start by drinking only once during the week and on weekends. Then I could work toward making sure I don’t drink more than one bottle of wine per week.

Identify resources and offer follow up

What people or groups in your life could help you while you work to cut back?

My book club would be helpful – they are all really supportive, and I know they would be there for me.

Offer follow up on plan progress in 4 to 6 weeks

Review Question

  1. Your last patient of the day is a 38 yo ‘soccer mom’ here for her well woman exam. She screened positive for excessive alcohol use on the annual wellness form she completed online prior to her visit, which you review with her after confirming she has no current complaints for this visit and her benign health history is unchanged.

    In discussing her drinking, using the decisional balance, she states that she likes drinking because it helps her relax and it’s just what her friends do when they get together. She dislikes that her drinking picked up during the pandemic and when she recently overheard her children, now teen and pre-teen, use the term ‘wine mom’ with their friends.

    She says she is a 5 on the readiness ruler. Your next step is to ask:

    1. “What negative consequences have you had because of your drinking, if any?”
    2. “Why are you a 5 and not a 3?” ”What would have to happen for you to be an 8?”
    3. “How do you plan to quit drinking tomorrow?”
    4. “Did you know drinking alcohol increases your breast cancer risk?”

This example video shows a brief intervention delivered in a primary care setting in under 3 minutes.

Note the three steps:

  1. Decisional balance to develop discrepancy
  2. Readiness ruler to identifying current stage of change
  3. Discussion targeted to stage of change to elicit change talk
Medication Treatment for Nicotine Use Disorder in Primary Care
Nicotine Use Disorder Treatment
Introduction

Medication Treatment for Nicotine Use Disorder in Primary Care


Learning Objectives

  1. List medication options for treating nicotine use disorder (NUD)
  2. Discuss incorporation of medications for nicotine use disorder (MNUD) in primary care.

Completion time: About 5 minutes

Review Question

  1. A 65-year-old male comes into your office for a check-up. He states that he has been feeling tired and short of breath but does not have any fevers or cough. He has a history of smoking 1 pack of cigarettes per day for the last 40 years.

    He cannot climb a set of stairs and states that he has been hospitalized many times over the past year for pneumonia. He is prescribed inhaled corticosteroids along with ipratropium and albuterol.

    Which of the following is most likely to decrease this patient's risk of hospitalizations for disease exacerbation and development of lung cancer?

    1. Home oxygen therapy
    2. Long acting beta2-agonist
    3. Antibiotics
    4. Smoking Cessation
Developing a Quit Plan: STAR

As part of a patient’s preparation for quitting, encourage them to take the following steps (STAR):

S

Set a quit date, ideally within 2 to 4 weeks.

T

Tell your family, friends, and coworkers about quitting and ask for their support.

A

Anticipate challenges, particularly during the critical first few weeks. Challenges include nicotine withdrawal symptoms.

R

Remove nicotine products from your environment. Prior to quitting, avoid using the nicotine product in places where you spend a lot of time (e.g. work, home, car). Make your home nicotine-free.

CLICK HERE for behavioral therapy information

Combining Behavioral and Pharmacotherapy

Combining Behavioral and Pharmacotherapy

  • Behavioral interventions alone increase smoking cessation at end of treatment and 6 months post treatment.
  • Medications alone increase smoking cessation at end of treatment and 6 months post treatment.
  • Offering both doubles the quit rates of each used alone.
  • Evidence-based behavioral therapies, individual or group, include cognitive behavioral, motivational and supportive therapies providing counseling, health education, feedback, financial incentives and social support.
  • Telephone counseling and mobile phone–based interventions focus on increasing motivation and likelihood of quitting:
Medications for Nicotine Use Disorder

First-line Medications for Nicotine Use Disorder




Nicotine Receptor
Agonists

Nicotine Replacement
(Patch, Gum, Lozenge,
Inhaler, Spray)

Nicotine Receptor
Antagonist

Bupropion-SR

Nicotine Receptor
Partial Agonist

Varenicline

FDA-Approved Tobacco Cessation Medications

Discuss, prescribe, and document tobacco cessation medication(s).

MedicationOTC/RxUseCost per dose
Nicotine patchOTCDaily-Steady state2.00$-2.92$ (daily dose)
Nicotine gumOTCPRN-Craving rescue0.27$-0.82$ per piece
(1.35-16.40$ for 5 to 20 pieces daily)
Nicotine lozengeOTCPRN-Craving rescue0.39$-0.40$
(1.95-8.00$ for 5 to 20 pieces daily)
Nicotine inhalerRxPRN-Craving rescue2.77$ per cartridge
(16.62-44.32$ for 6-16 cartridges daily)
Nicotine nasal sprayRxPRN-Craving rescue6.11$ per 40mg or
80 sprays average daily
Bupropion SR 150RxDaily-Steady state0.99-1.13$ (daily dose)
VareniclineRxDaily-Steady state8.42$ (daily dose)

Click on each medication for more information

Nicotine Patch
Dosing
Light Smoker (< 10 cigarettes per day)
  • Step 1: 14 mg x 6 wks
  • Step 2: 7 mg x 2 wks
Heavy Smoker (> 10 cigarettes per day)
  • Step 1: 21 mg x 6 wks
  • Step 2: 14 mg x 6 wks
  • Step 3: 7 mg x 2 wks
Administration
  • Apply one new patch daily to non-hairy portion of chest, back, abdomen, upper arm
  • Each patch can stay on for 16 to 24 h
  • May start patch before quit date
  • Rotate application site
Side Effects
Common side effects include:
  • Skin irritation, insomnia, vivid dreams
  • Can use OTC hydrocortisone 1% cream for skin irritation
  • Avoid use in patients with dermatological conditions (e.g., psoriasis, eczema, atopic dermatitis)
Advantages
  • Provides steady nicotine level
  • Easiest nicotine product to use
Precautions
  • User cannot alter nicotine level in case of craving
  • Recent (≤ 2 wks) myocardial infarction
Other
  • Remove for sleeping to avoid insomnia, vivid dreams
Nicotine Gum
Dosing
  • 2 mg if first cigarette > 30 minutes after waking up
  • 4 mg if first cigarette within 30 minutes of waking up
  • Weeks 1–6: 1 piece q 1–2 h
  • Weeks 7–9: 1 piece q 2–4 h
  • Weeks 10–12: 1 piece q 4–8 h
Administration
  • One piece every hour
  • Maximum: ≤ 24 pieces/day
  • No food or drink for 5-15 minutes before, during and after use
  • Bite once or twice until pepper taste/tingling sensation then cheek.
  • Repeat for up to 30 minutes per piece.
Side Effects
Common side effects include:
  • Mouth soreness
  • Jaw muscle ache
  • Heartburn
  • Hiccups
  • Nausea
  • (gastrointestinal side effects usually due to overly vigorous chewing)
Advantages
  • Able to control nicotine dose
  • Oral substitute for cigarettes
Precautions
  • Unpleasant taste especially if chewed like regular gum
  • May stick to dental work. Difficult for denture wearers to use.
  • Recent (≤ 2 wks) myocardial infarction
Other
  • Proper chewing technique required (chew and cheek)
Nicotine Lozenge
Dosing
  • 2 mg if first cigarette ≥ 30 min after waking
  • 4 mg if first cigarette < 30 min after waking
Administration
  • One piece every one to two hours
  • Maximum:
    • 5 lozenges/six hours
    • 20 lozenges/day
  • No food or drink for 5-15 minutes before, during and after use
Side Effects
Common side effects include:
  • Mouth soreness
  • Hiccups
  • Heartburn
  • Nausea
Advantages
  • Able to control nicotine dose
  • Oral substitute for cigarettes
  • Can be used by smokers with poor dentition or dentures
Precautions
  • Unpleasant taste
  • Recent (≤ 2 wks) myocardial infarction
Other

n/a

Nicotine Inhaler
Dosing
  • 10 mg per cartridge
  • Delivers 4 mg nicotine vapor, buccal mucosa
  • At least 8 cartridges/day for the first 3-6 weeks
Administration
  • To use 1 cartridge every 1-2 hours
  • Maximum:16 cartridges per day
  • Duration of therapy is 3 months
Side Effects
Common side effects include:
  • Mild mouth and throat irritation
  • Cough
  • Rhinitis
  • Headache
  • Dyspepsia
Advantages
  • Able to control nicotine dose
  • Oral substitute for cigarettes.
Precautions
  • Device visible when being used
  • Use caution in reactive airway disease
Other
  • Frequent puffing required
Nicotine Nasal Spray
Dosing
  • 0.5 mg per spray (10 mg/mL)
Administration
  • Apply one spray to each nostril every one to two hours
  • Maximum:
    • 10 sprays/hour
    • 80 sprays/day
Side Effects
Common side effects include:
  • Hot peppery feeling in back of throat or nose
  • Sneezing
  • Coughing
  • Watery eyes
  • Runny nose
Advantages
  • Able to control nicotine dose
  • Rapid absorption across nasal mucosa
Precautions
  • Local irritation to nasal mucosa is difficult for many to tolerate
Other
  • Side effects wear off after regular use during the first week
Bupropion Sustained Release
Dosing
  • 150 mg pill
Administration
  • 150 mg/day for three days, then 150 mg twice a day
  • Start 1-2 weeks before quit date
  • Abruptly quitting smoking is preferred
  • Gradual smoking reduction is an alternative:
    • reduce smoking by 50% by week 4,
    • then another 50% by week 8,
    • then quit by week 12
Side Effects
Common side effects include:
  • Insomnia
  • Agitation
  • Dry mouth
  • Headache
  • Weight loss
  • Constipation
Advantages
  • Blunts post-cessation weight gain while being used
Precautions
  • Contraindicated in patients with seizure disorder or predisposition, eating disorder
  • Monitor for neuropsychiatric symptoms:
    • Behavioral changes
    • Hostility
    • Agitation
    • Depressed mood
    • Suicidal ideation and attempts
Other
  • May be used as monotherapy or in combination with nicotine replacement therapy
Varenicline
Dosing
  • 0.5 mg pill to start, then titrate up to 1 mg pill
Administration
Schedule:
  • Days 1 to 3: 0.5 mg/day
  • Days 4 to 7: 0.5 mg twice daily then 1 mg twice daily
Duration of therapy: 12 weeks.
  • Start at least 1 -2 weeks before quit date
  • OR may begin treatment and quit between Days 8 and 35
Approaches to selecting a tobacco quit date:
  • May either choose a fixed quit date (i.e., start drug then quit on day 8)
  • or a flexible quit date (i.e., start drug, then quit between days 8 to 35)
  • Alternatively, a gradual quit date:
    • start drug and reduce smoking 50% by week 4,
    • reduce an additional 50% by week 8,
    • and continue reducing with a goal of complete abstinence by week 12
Side Effects
Common side effects include:
  • Nausea,
  • Insomnia
  • Abnormal dreams (vivid, unusual or strange)
  • Headache
  • Skin rash (≤ 3%)
Advantages
  • Dual action: relieves nicotine withdrawal and blocks reward from smoking
  • Oral agent (pill)
Precautions
  • Reduced dose in severe renal insufficiency
  • Avoid in patients with unstable psychiatric status or history of suicidal ideation or PTSD
  • Monitor for neuropsychiatric symptoms (behavioral changes, hostility, agitation, depressed mood, suicidal ideation and attempts)
Other
  • Abruptly quitting smoking is preferred
  • For patients unable/unwilling to quit abruptly: offer a gradual approach to quitting (over 12 weeks)

Review Question

  1. A 58-year-old woman presents to her family physician for an annual checkup. During the visit, the patient asks her physician for help quitting smoking cigarettes. She has unsuccessfully tried quitting several times previously and has also failed prior attempts with meditation and exercise. The physician prescribes a partial agonist of the nicotinic receptor to aid the patient in cessation.

    Which of the following is a potential side effect of this medication?

    1. Seizure
    2. Sexual dysfunction
    3. Suicidal ideation
    4. Tachycardia
Electronic Nicotine Delivery Systems (ENDS)

About Electronic Nicotine Delivery Systems (ENDS)

What are ENDS?
Are ENDS less harmful than cigarettes and other forms of tobacco?
Can ENDS be used for tobacco cessation?
What medications can be used for patients wanting to quit ENDS?

Click on each question for more information

Electronic Nicotine Delivery Systems (ENDS)

What are ENDS?

  • Vapes, vaporizers, vape pens, hookah pens, electronic cigarettes (e-cigarettes or e-cigs), and e-pipes are some of the many terms used to describe electronic nicotine delivery systems (ENDS).
  • Some e-cigarettes are made to look like regular cigarettes, cigars, or pipes. Some resemble pens, USB sticks, and other everyday items.
  • Contain a heating element to vaporize a liquid that can include flavor compounds, nicotine, propylene glycol, and/or cannabis-derived compounds such as tetrahydrocannabinol (THC) and cannabidiol (CBD)
  • Nicotine pods typically contain the same or more nicotine per unit than a pack of cigarettes.

Cigarette vs Vaping pen
Electronic Nicotine Delivery Systems (ENDS)

Are ENDS less harmful than cigarettes and other forms of tobacco?

Cigarette vs Vaping pen

E-cigarette aerosol generally contains fewer toxic chemicals than the deadly mix of 7,000 chemicals in smoke from regular cigarettes. However, e-cigarette aerosol is not harmless. It can contain harmful and potentially harmful substances, including nicotine, heavy metals like lead, volatile organic compounds, and cancer-causing agents.

Electronic Nicotine Delivery Systems (ENDS)

Can ENDS be used for tobacco cessation?

  • In October 2021, the FDA authorized the marketing of specific, tobacco-flavored ENDS products. Manufacturers’ data demonstrate that these products can benefit adults with TUD who switch to them – either completely or with a significant reduction in cigarette consumption – by reducing their exposure to harmful chemicals.
  • Smokers who try to quit by using ENDS often do so by using ENDS with lower and lower concentration of nicotine, until they are using a nicotine-free product, then attempt to stop that as well either cold-turkey or by tapering frequency of use at that point.
Electronic Nicotine Delivery Systems (ENDS)

What medications can be used for patients wanting to quit ENDS?

  • There are no FDA approved medications specifically for ENDS cessation.
  • The current consensus approach is to use FDA approved medications for treating TUD, both OTC and Rx, to help patients stop ENDS.
Combination Therapy

Use of Combination Therapy

Combining medications for NUD

Some studies suggest that combining NRT with other medications may facilitate cessation. For example, a meta-analysis found that a combination of varenicline and NRT (especially, providing a nicotine patch prior to cessation) was more effective than varenicline alone.

Similarly, adding bupropion to NRT also improved cessation rates.

For smokers who could not cut down significantly by using the NRT patch, combining extended-release bupropion and varenicline was more effective than placebo, particularly for men and those who were severely nicotine dependent.


Combining and prioritizing NUD treatment with treating other SUDs

Nicotine use disorder, in the form of cigarette smoking, causes greater morbidity and mortality than any other single use disorder and all others’ combined risks.

Three in four adults with alcohol use disorder and 9 in 10 adults with other substance use disorders smoke tobacco.

Early-onset cigarette use is a significant predictor of lifetime drinking, more excessive alcohol consumption, and the subsequent development of lifetime alcohol use disorders.

Among individuals treated for alcohol use disorders, tobacco-related diseases were responsible for half of all deaths, greater than alcohol-related causes.

While concomitant tobacco smoking and other substance use are common, treating NUD may improve sobriety outcomes in the long term. A meta-analysis of randomized controlled tobacco cessation trials with smokers in treatment for substance use disorders found tobacco cessation interventions were associated with a 25% increased likelihood of sobriety from alcohol and other substances relative to usual care.

Review Question

  1. A 35-year-old man presents to his primary care physician for a routine visit. He is in good health but has a 15 pack-year smoking history. He has tried to quit multiple times and expresses frustration in his inability to do so. He states that he has a 6-year-old son that was recently diagnosed with asthma and that he is ready to quit smoking.

    What is the most effective method of smoking cessation?

    1. Quitting “cold turkey”
    2. Bupropion in conjunction with nicotine replacement therapy and behavioral therapy
    3. Bupropion alone
    4. Nicotine replacement therapy alone
Medication Treatment for Alcohol Use Disorder in Primary Care
Alcohol Use Disorder Treatment
Introduction

Medication Treatment for Alcohol Use Disorder in Primary Care


Learning Objectives

  1. List medication options for treating alcohol use disorder (AUD).
  2. Discuss incorporation of medications for alcohol use disorder (MAUD) in primary care.

Completion time: About 5 minutes

Medications for AUD Treatment

Medications for AUD Treatment in Adults - Withdrawal Management

MedicationRouteFormulationRecommended daily doseHalf-lifeCostSide effectsPrecautionsOther
Withdrawal Management
Benzodiazepines
Chlordiazepoxide (Librium)Oral5mg, 10mg, 25mgSymptom-driven or fixed dose-and-taper protocolsIntermediate acting (10-30 hours)0.18$-4.33$
per unit
Confusion, drowsiness, restlessness, irritability, tolerance, misuseDose adjustment in elderly, psychiatric patients, hyperactive aggressive pediatric patientsHistorically preferred for patients with possible liver dysfunction
Diazepam (Valium)Oral10mgSymptom-driven or fixed dose-and-taper protocolsLong acting (20-100 hours)0.14$-4.88$
per unit
Confusion, drowsiness, restlessness, irritability, tolerance, misusePregnancy, other substance use disorder, depression, seizures, glaucoma
Lorazepam (Ativan)Oral0.5mg, 1mg, 2mgSymptom-driven or fixed dose-and-taper protocolsShort acting (10-20 hours)0.39$-0.56$
per unit
Confusion, drowsiness, restlessness, irritability, tolerance, misuseKidney disease, liver disease, glaucoma, psychosis, other substance use
Phenobarbital (Luminal)Oral15mg, 16.2mg, 30mg, 32.4mg, 60mg, 100mg tabs, 20mg/5ml elixirSymptom-driven or fixed dose-and-taper protocols80-120 hours0.09$-0.79$
per unit
Somnolence, sedation, restlessness, could lead to respiratory depressionOther substance use, pregnancy, carcinogenicNarrow therapeutic window, considered third-line to benzodiazepines and GABA-ergics; monitor blood levels or reflexes for toxicity
GABA-ergics
Carbamazepine (Tegretol)Oral100mg, 200mg, 300mg800mg Day 1 tapering to 200mg Day 4 in divided doses35-40 hours0.20$-1.21$
per unit
Blurred vision, continuous back and forth eye movements, diarrhea, headachesUse of MAO inhibitor, psychosis, history of suicide, light sensitivity
Gabapentin (Neurontin)Oral200mg, 300mg, 400mg600 - 1200 mg divided into 2 to 3 doses daily, tapering over 4 to 7 days5-7 hours0.14$-4.17$
per unit
Ataxia, dizziness, drowsiness, fatigueMental illness, seizures, pregnancyPhysical dependence and misuse have been noted
Valproic acid (Depakote)Oral500mg: One twice daily for 5 to 7 days4-16 hours0.32$-0.40$/
250mg tab
Drowsiness, diarrhea, headache, weight changesBreastfeeding, drowsiness

Medications for AUD Treatment in Adults - Relapse Prevention

MedicationRouteFormulationRecommended daily doseHalf-lifeCostSide effectsPrecautionsOther
Relapse Prevention
On-label
Acamprosate (Campral)Oral333mg2 x 333mg tab po TID or 3 x 333mg tab po BID20-33 hours$70-200
/month
Diarrhea, nausea, depression, anxietyDose adjustment for CrCl 30-50ml/min; unstable depression or suicidalityPatient selection: Impulsivity issues or protracted withdrawal symptoms
Disulfiram (Antibuse)Oral125mg, 250mg, 500mg250 mg once daily60-120 hours$54.90
/month
Metallic taste, dermatitisPsychosis, DM, epilepsy, hepatic dysfunction, thyroid disease, renal impairment, dermatitisPatient selection: highly motivated, monitored
Naltrexone (ReVia – oral) (Vivitrol – IM)Oral, IM50mg tab, 380mg IM50mg tab po qday
380mg IM qmonth
4-13 hoursTabs: $130-300+
/month

Single dose vial: $700-800 /month
Nausea, abdominal pain, constipation, dizziness, headache, anxiety, fatigueLiver disease, renal impairment, history of suicide attemptsPatient selection: family history of alcohol dependency or concurrent Cognitive Behavioral Therapy (CBT)
Off-label
Gabapentin (Neurontin)Oral200mg, 300mg, 400mg600-1200mg divided into 2 to 3 doses daily, tapering over 4 to 7 days5-7 hours$8-250/
month
Ataxia, dizziness, drowsiness, fatigueMental illness, seizures, pregnancyPhysical dependence and misuse have been noted
Topiramate (Topamax)Oral25mg, 50mg, 100mg tabs300mg/day po max19-23 hours$9-500/
month
Numbness and tingling, change in taste, decreased appetite, concentrationRenal impairment with dose adjustment for CrCl
< 70ml/min, depression, glaucoma
Patient selection: Can start non sober
BaclofenOral5mg, 10mg, 20mg tabsno set upper limit, minimal impact below 60-80mg daily dose, 140-180mg typical in European literature, doses much higher reported2-6 hours$60-300/
month
Drowsiness, dizziness, weakness, nausea, confusion, urinary retentionRenal impairment (cleared renally), h/o seizure disorder, avoid abrupt discontinuation, peptic ulcer disease, decreases GI motility, h/o psychosisTypically reserved for patients non-responsive to or with contraindications to other medications, i.e., not used first-line, Non sober start okay, Titrate by 10mg q3 days to effective dose
2 Phases of AUD Treatment

Alcohol Use Disorder treatment involves 2 phases

Withdrawal Management

Can often be safely conducted in the ambulatory setting

Can be accomplished using symptom driven vs fixed-dose-and-taper protocols

Relapse Prevention

After abstinence initially achieved or started along with withdrawal management, relapse prevention can include:

Let’s take a closer look... click on each underlined term above

Determining the safety of ambulatory, medically managed alcohol withdrawal
Questions to ConsiderAmbulatory Setting SafeInpatient or Residential
Treatment Setting Safer
What is the patient’s home environment? Patient has a safe, sober, supportive home environment Patient lives alone, is undomiciled or has unstable housing, is experiencing active and ongoing trauma (abuse), or there is ongoing substance use by others
What is the patient’s cognitive status? Patient is cognitively intact enough to safeguard their medication and take it as prescribed or have someone who is able and willing to help them manage the medications Patients with cognitive impairment that precludes their adherence to medication protocols and who doesn’t have anyone who is able and willing to manage their medications for them
What is the patient’s current medical and psychiatric status? Any underlying medical and/or psychiatric conditions are stable, and patient does not have a lowered seizure threshold Underlying medical and/or psychiatric conditions are unstable, or lowered seizure threshold whether from medications (e.g., some neuroleptics, tramadol, theophylline), underlying seizure disorder, or concomitant cessation of other substances (e.g., benzodiazepines, GABA-ergics)
What is the patient’s prior experience with alcohol withdrawal? Patient has no history of withdrawal seizures or delirium tremens Patient with prior history of withdrawal seizures or delirium tremens is at heightened risk of these complications with subsequent withdrawal episodes, known as the ‘kindling effect’
What is the patient’s current substance use pattern? Patient is only using alcohol with or without concurrent nicotine use Patient is using other substances, excepting nicotine, in addition to alcohol, especially substances with physical withdrawal syndromes requiring pharmacological management, i.e., benzodiazepines and/or opioids
Medically Managed Alcohol Withdrawal Protocols
Symptom Driven
  • Benzodiazepine is dosed based on Clinical Institute Withdrawal Assessment for Alcohol Revised (CIWA-Ar) scoring
  • CIWA-Ar administration frequency decreases as withdrawal symptoms stabilize and improve
  • Used in the hospital or residential treatment setting as requires clinical judgement in addition to CIWA-Ar assessment for management decisions
  • Decreases total amount of medication needed and length of withdrawal episode
  • Click for a sample symptom driven protocol
Fixed-Dose and Taper
  • More often used in ambulatory and outpatient settings
  • Taper over 3 to 5 days most typical
  • GABA-ergics preferred if patient has risk for misuse or overdose with benzodiazepines
  • Click for sample benzodiazepine and GABA-ergic fixed-dose and taper protocols

Click on each underlined term above for more information

CIWA-Ar

CIWA-Ar Assessment Tool

Symptom driven
Sample symptom driven treatment protocol
Protocol medication: Chlordiazepoxide 25mg, Diazepam 10mg or Lorazepam 2mg
  • Monitor vital signs and CIWA-Ar every hour upon admission until CIWA-Ar < 8 for two consecutive hours,
  • Then monitor vital signs and CIWA-Ar q 2 hours until CIWA-Ar < 8 over four consecutive hours,
  • Then monitor vital signs and CIWA-Ar q4 hours until CIWA-Ar < 8 over eight consecutive hours,
  • Then monitor vital signs and CIWA-Ar every 8 hours until CIWA-Ar < 8 over sixteen consecutive hours, then stop protocol.
  • Give one dose of protocol medicine if CIWA-Ar > 8 and resume monitoring vital signs and CIWA-Ar hourly as above.
  • Notify medical staff if: BP > 160/100 or < 85/50, HR > 110 or < 50, RR > 22 or < 10, T > 101F, CIWA-Ar > 20
  • Oral adjuncts: folic acid 1mg daily, thiamine 100mg daily, ondansetron 8mg every 8 hours as needed for nausea/vomiting, trazadone 100mg or melatonin 6 mg as needed for sleep, Depakote ER 500mg twice daily, nicotine patch as needed for nicotine withdrawal.
Benzodiazepine and GABA-ergic
Sample fixed-dose and taper protocols
Benzodiazepine, oral dosing:
Chlordiazepoxide 25mg, Diazepam 10mg or Lorazepam 2mg

Day 1: Take one every 6 hours

Day 2: Take one every 8 hours

Day 3: Take one every 12 hours

Day 4 and 5: Take one at bedtime


Do NOT drink ANY alcohol while taking this medication. Do not drive or operate heavy machinery while taking this medication. If withdrawal symptoms or cravings intolerable, notify clinician and/or seek emergency care immediately.

Oral adjuncts: folic acid 1mg daily, thiamine 100mg daily, ondansetron 8mg every 8 hours as needed for nausea/vomiting, trazadone 100mg or melatonin 6 mg as needed for sleep

GABA-ergic oral dosing

Carbamazepine 200 mg:

Day 1: Take one every 6 hours

Day 2: Take one every 8 hours

Day 3: Take one every 12 hours

Day 4: Take one at bedtime


Valproic acid 500mg:

Take one twice daily for 5 to 7 days


If withdrawal symptoms or cravings intolerable, notify clinician and/or seek emergency care immediately.

Oral adjuncts: folic acid 1mg daily, thiamine 100mg daily, ondansetron 8mg every 8 hours as needed for nausea/vomiting, trazadone 100mg or melatonin 6 mg as needed for sleep

Non-medication Modalities
Behavioral Therapies
  • Cognitive Behavioral Therapy
  • Contingency Management
  • Motivational Interviewing
  • Twelve Step Facilitation

Many community-based treatment facilities incorporate a variety of behavioral therapies into their programming. Length of engagement with a program that uses evidence-based therapies is a better predictor of sustained recovery than type of therapy received. For patients with emotional, physical, sexual and/or verbal abuse histories, provision of or referral to trauma-informed services is crucial.

Behavioral therapies can be successfully delivered in the ambulatory primary care setting within integrated practices by a licensed counselor, within co-occurring behavioral health practices, and in formal SUD treatment programs in both outpatient and residential treatment settings. Most outpatient treatment programs offer sessions mornings, afternoons and evenings to accommodate caretaker, student and worker schedules, meeting for 2 hours 2 to 5 days a week, with weekend programming incorporating family programming.

Mutual-Aid Fellowships
  • 12 Step
    • Alcoholics Anonymous (AA): open to persons who desire to stop drinking; a person does not have to be sober or already in recovery to attend
    • Alanon: open to persons who are struggling with AUD in their family
    • Alateen: open to teens and young adults with AUD in their family
  • Smart Recovery
    • Does not involve acknowledgement of a ‘higher power’

Mutual-aid fellowships provide access to a sober support network with groups held around the world and around the clock. Each group will have their own ‘personality’. Encourage the patient to explore several groups for a few meetings each to see which one/s may be more helpful for them, if any. Fellowships help members celebrate recovery milestones. Attendees are not required to speak during meetings. Attending 90 meetings in 90 days has been shown to be helpful to achieving longer term fellowship participation and sobriety, as has having a sponsor, who is typically an established member of the fellowship with five or more years in recovery.

Review Question

  1. Ms. B is a 20 year old patient here for a contraception visit. She screens positive on your practice’s alcohol screening questionnaire and on further discussion says she would like to quit, has tried cutting back herself but ‘that never works; if I have one, I’m not remembering the rest of the night’. She is a college student and was only drinking on the weekends, but now drinks 5 to 6 nights out of the week, ‘a lot, until I pass out, I guess 10-12 shots and a few beers too’. She denies use of any other substance except cannabis which she smokes once every week or two as it usually makes her more paranoid than relaxed. She takes a cannabidiol ‘gummy’ or two daily. She has no other medical problems or history, no psychiatric history, is not suicidal and is taking no other medications besides depo provera every 3 months. She is passing her classes this semester but barely. She has no history of seizures and no prior treatment for substance use of any kind. She moved back in with her parents, who are sober and supportive, after last semester as they hoped the move would help her cut back on ‘partying’. She wants to finish out the semester as if she takes a leave of absence she will lose a needed scholarship.

    You suggest:

    1. 1. Referral to a residential program for medical management of withdrawal and then 30 days of residential treatment
    2. 2. Ambulatory withdrawal and AA attendance
    3. 3. Ambulatory withdrawal and referral to an intensive outpatient treatment program
    4. 4. Option of 2 or 3
Prescribing AUD Medication

Prescribing Relapse Prevention Medication in Practice

Review Question

  1. Mr. A is a 61 year old well known to your practice. He has diabetes, hypertension and hypercholesterolemia and was recently admitted to the hospital for shortness of breath and diagnosed with congestive heart failure. You are seeing him today for his post-discharge follow-up visit. In reviewing his hospital records prior to today’s visit, you note that he was also treated for alcohol withdrawal. In reviewing his inpatient test results, you note his echocardiogram was suggestive for alcoholic cardiomyopathy and his liver function tests were slightly elevated at less than two times the upper limit of normal.

    During the visit with Mr. A, he somewhat sheepishly mentions that while he hasn’t started drinking again, he has been depressed since his recent divorce and thinking about ‘having a cold one, just one’ the last two days. He’s been stressed from this recent ‘health scare’ and with missing work. He is worried about how going back to drinking would affect his health.

    You suggest:

    1. Starting acamprosate for relapse prevention
    2. Starting disulfiram for relapse prevention
    3. Starting naltrexone for relapse prevention
    4. Another alcohol ‘detox’ with lorazepam
Medical Complications of AUD

Medical Complications of AUD: Providing care in long term recovery

Care of a patient with AUD, whether actively using or in long term recovery involves monitoring for medical problems and conditions caused by or risk increased by alcohol use:
  • Cardiovascular: Alcohol is a direct cardiotoxin where long-term, heavy use is associated with a higher risk of cardiomyopathy. Alcoholic cardiomyopathy should be considered in patient with congestive heart failure symptoms with a history of AUD. Routine, asymptomatic screening is not recommended.
  • Gastrointestinal: Alcohol is also a direct irritant of the gastrointestinal mucosa, and chronic consumption can lead to gastritis, ulcers and esophageal and stomach cancers. Alcohol is also liver toxic, with injury progressing from reversible fatty liver changes to irreversible cirrhosis, which raises the risk of liver cancer significantly. Alcohol is also the most common etiology of pancreatic disease in the US.
  • Neurological: Alcohol is a direct neurotoxin and increases dementia risk, is a common etiology of peripheral neuropathy and can cause long term damage to the cerebellum impacting gait and balance.
  • Hematological: Alcohol consumption can lead to a macrocytic anemia. It also directly inhibits platelet clotting function, and can also decrease platelet production with chronic, heavy use.
  • Ob/Gyn: Alcohol is a potent teratogen with fetal alcohol spectrum disorders and the leading preventable cause of developmental disorders in the US. There is no safe amount, type or frequency of alcohol consumption during pregnancy. Alcohol also linearly increases the risk of breast cancer.
  • Psychiatric: Alcohol is a depressant, and co-occurring disorders are prevalent in patients with AUD including other substance use disorders, especially nicotine use disorder, bipolar disorder and generalized anxiety disorder. Insomnia is frequently encountered in early recovery and should be anticipated.

Review Question

  1. At a follow up visit 3 months later, Mr. A reports continued sobriety with no cravings. He has had no intervening episodes of sudden weight gain, chest pain or shortness of breath. Pre-visit lab results show his diabetes control is improving as are his cholesterol levels, especially triglycerides. However, his liver function tests are now two and a half times the upper limit of normal. His chief complaint today is ‘taking too many pills…I feel like a chicken pecking corn’. He asks about stopping the naltrexone.

    You recommend:

    1. 1. Continuing naltrexone for 3 more months
    2. 2. Tapering the naltrexone now with follow up in 3 months
    3. 3. Stopping the naltrexone now with follow up in 1 month
    4. 4. A choice between 1 and 3
    5. 5. A choice between 1 and 2
Medication Treatment for Opioid Use Disorder in Primary Care
Opioid Use Disorder Treatment
Introduction

Medication Treatment for Opioid Use Disorder in Primary Care


Learning Objectives

  1. List medication options for treating opioid use disorder (OUD).
  2. Discuss incorporation of medications for opioid use disorder (MOUD) in primary care.

Completion time: About 5 minutes

Opioid Use Disorder Treatments

Opioid Use Disorder Treatments

Use of medications to treat Opioid Use Disorders is recognized as the gold standard for treating OUD, as 4 out of 5 people with OUD will chronically relapse when treated with non-medication therapies alone. Medications have shown efficacy with and without behavioral counseling.

Many patients with OUD find the addition of behavioral therapies to be beneficial in addressing co-morbid mental health issues, including help in processing traumas such as current physical abuse or a history of childhood sexual abuse. Trauma is common in patients with OUD, especially women. Residential treatment services and sober living housing can be helpful for patients who don’t have a safe, sober, supportive home environment.

Most but not all behavioral treatment settings support patients taking Medications for Opioid Use Disorders (MOUD). Some programs do not permit patients receiving their services to continue or start MOUD. It is important to know which treatment providers you can refer patients to that will support the full spectrum of care for patients on MOUD.

Next we’ll explore the three classes of medications for treating OUD.

Review Question

  1. Ms. C is a 32 yo new patient who comes to your office for renewal of her pain medication (hydrocodone/acetaminophen) which she has been taking for the last 4 years for back pain. She states her previous physician recently relocated out of the area. She started taking the opioid pills after a C-section. She has continued them as she found that they helped with back pain which began in her third trimester. Every time she has tried to taper off, her back pain returns along with pain in her other joints. Over the last 4 years she has gone from taking 1 to 2 a day to now taking 8 to 10 daily. She can barely get out of bed if she doesn’t have her medication but finds herself nodding out midday which scares her since she is home alone with her 4-year-old, who is quite active. She’d really like to get off the opioids especially since a cousin overdosed on pain pills last year, but she has resigned herself that her body is too sick without them.

    What is the gold standard treatment for OUD which you can recommend to Ms. C?

    1. Detoxification and 30 days of residential treatment
    2. Detoxification and 90 days of residential treatment
    3. Narcotic Anonymous attendance, 90 meetings in 90 days
    4. Medication treatment (MOUD)
Medications for OUD

FDA Approved Medications for Opioid Use Disorder Treatment in Adults

Agonists

(Fully activates opioid receptors)

Reduces opioid cravings and withdrawal and blunts or blocks the effects of other opioids

Partial Agonist

(Activates opioid receptor but produces a diminished response even with full receptor saturation)

Suppresses withdrawal and reduces cravings for opioids

Antagonist

(Competitively blocks opioid receptors, interfering with the rewarding and analgesic effects of opioids)

Blocks the euphoric and sedative effects of opioids and may reduce cravings

Click on each drug name for more information

Methadone - Schedule II controlled medication
Dosing
Drug nameDosingImage
Dolophine / Methadose60 to 120 mg/day
Administration
  • Once daily, oral liquid
  • MUST BE ORDERED AND DISPENSED BY A LICENSED Opioid Treatment Program (OTP) when used to treat OUD
Side Effects
Common side effects include:
  • Restlessness
  • Nausea or vomiting
  • Slow breathing
  • Itchy skin
  • Heavy sweating
  • Constipation
  • Sexual dysfunction
Advantages
  • High strength and efficacy when oral dosing is adhered to
  • Excellent option for patients who have no response to other medications and/or who need the accountability of frequent clinic visits
  • Women who are pregnant or breastfeeding can safely take methadone
Disadvantages
  • Available ONLY through OTPs
  • Initially requires daily visits to clinic for mandated directly observed dosing
  • Stigma
  • Multiple drug-drug interactions including with HIV medications
  • Associated with prolonged QT interval
Available through
Cost*
Drug nameCost per dose  
Dolophine / Methadose$ 240
*Cost estimates are based on an average target dose/day for 1 month (Drugs.com, 09/25/20)
Buprenorphine - Schedule III controlled medication
Dosing and Administration
Drug nameDosingAdministrationImage
Buprenorphine (Generic) 8 to 16 (max 24) mgSublingual tablet
- Sublocade   (Indivinor) Initial: 300 mg monthly
for 2 months;
Maintenance: 100 mg monthly
Subcutaneous extended-
release injection
Buprenorphine/Naloxone (Generic) Formulation:
2/0.5 mg, 8/2mg

Recommended Once-Daily /
Maintenance Dose

Target: 16 /4 mg
Range: 4 /1 mg to 24 /6 mg
Sublingual tablet
- Suboxone (Reckitt Benkiser)Formulation:
2/0.5 mg, 4/1 mg, 8/2mg, 12/3 mg

Recommended Once-Daily /
Maintenance Dose

Target: 16 /4 mg
Range: 4 /1 mg to 24 /6 mg
Sublingual film
- Zubzolv SL (Orexo)Formulation:
1.4/0.36 mg, 5.7/1.4 mg, 8.6/2.1 mg, 11.4/2.9 mg

Recommended Once-Daily /
Maintenance Dose

Target: 11.4 /2.9 mg
Range: 2.9 0.71 mg to 17.2 /4.2 mg
Sublingual tablet
- Bunavail
  (Biodelivery Sciences)
Formulation:
2.1/0.3 mg, 4.2/0.7 mg, 6.3/1 mg

Recommended Once-Daily /
Maintenance Dose

Target: 8.4 /1.4 mg
Range: 2.1 /0.3 mg to 12.6 /2.1 mg
Buccal film
Side Effects
Common side effects include:
  • Constipation, headache, nausea, and vomiting
  • Dizziness
  • Drowsiness and fatigue
  • Sweating
  • Dry mouth
  • Muscle aches and cramps
  • Inability to sleep
  • Fever
  • Blurred vision or dilated pupils
  • Tremors
  • Palpitations
  • Disturbance in attention
Advantages
  • Improved safety, i.e., decreased overdose risk especially in opioid-dependent patients due to its partial agonist activity at the opioid receptor
  • Can be taken by persons who are pregnant or breastfeeding
  • Available as an office-based treatment
Disadvantages
  • Buprenorphine has measurable abuse liability especially if injected
  • Formulations, such as Suboxone, compounding buprenorphine with the opioid antagonist naloxone, decrease this risk as naloxone has little bioavailability when taken by non-injection route but induces withdrawal when injected.
Available through
  • Any health care provider with Schedule III controlled substance prescribing authority (i.e. a standard DEA certificate).
Cost*
Drug nameCost per dose  
Buprenorphine (Generic) $30-$180 (dose dependent)
- Sublocade (Indivinor)$ 1,741.50
Buprenorphine/Naloxone (Generic) $90-$270 (dose dependent)
- Suboxone (Reckitt Benkiser)$240-$900 (dose dependent)
- Zubzolv SL (Orexo)$180-$540 (dose dependent)
- Bunavail (Biodelivery Sciences)$ 550.52
*Cost estimates are based on an average target dose/day for 1 month (Drugs.com, 01/27/23)
Naltrexone-ER  XR-NTX  Unscheduled medication
Dosing and Administration
Drug nameDosingAdministrationImage
Naltrexone ER - Vivitrol (Alkermes)380mg monthlyIntramuscular injection
Side Effects
Common side effects include:
  • Nausea
  • Anxiety
  • Insomnia
  • Depression
  • Dizziness
Advantages
  • No abuse potential or diversion risk
  • Non-sedating and does not result in physical dependence
  • Available as an office-based treatment
  • Option for individuals seeking to avoid any opioids
  • Depot formulation shows similar efficacy to agonist and partial agonist therapies
Disadvantages
  • Depot formulation shows similar efficacy to agonist and partial agonist therapies.
  • Initiation requires 10 days of opioid abstinence, during which withdrawal, relapse, and early dropout may occur
Available through
  • Any health care provider with prescribing authority
Cost*
Drug nameCost per dose  
Naltrexone ER - Vivitrol (Alkermes)$ 1,458.09
*Cost estimates are based on an average target dose/day for 1 month (Drugs.com, 09/25/20)

What are the advantages and disadvantages to providing MOUD within a primary care office-based setting (OBOT)?

Advantages
Perceived as less stigmatizing than attending a traditional non-medication-based treatment program or an opioid agonist treatment program (methadone clinic)
Recognizes and reinforces that OUD is a chronic disease within the scope of regular medical practice – and that stabilizing a person’s OUD is important to their overall health
In many areas, specialty OUD treatment is not available or there are long waits for treatment services
Primary care clinicians who treat patients for chronic pain have an effective modality for addressing OUD that can inadvertently result from chronic pain treatment with opioids while still offering some analgesia
Disadvantages
May not provide enough structure and support for patients with complex or uncontrolled psychiatric morbidities
Doesn’t provide patients with a sober, safe, supportive recovery environment if their current home environment is lacking
Partial agonist therapy (e.g., buprenorphine) may not provide sufficient opioid receptor activation to stem cravings and withdrawal in a person with extremely high opioid tolerance (eg to fentanyl)
Patients wanting non-agonist medication treatment option (eg naltrexone) will need opioid withdrawal management and to tolerate a 7 to 10 day ‘wash-out’ period before beginning treatment, that is often not well tolerated nor successfully completed outside of a controlled setting

Deciding if a patient is a good candidate for OBOT

  • Can they afford visit, lab and medication co-pays?
  • Can they get to appointments, have adequate transportation or can take time off work or have time and technology for telehealth visits?
  • Are there any medical or other psychiatric conditions too unstable for the patient to engage in OBOT?
  • Does the patient’s job, school or criminal justice system involvement routinely test for drugs or restrict use of any of the medications for OUD?
  • Do they have a place to live and to safely store the medication?
  • Is anyone they live with actively using other substances besides tobacco?
  • Is anyone they live with emotionally, physically, sexually or verbally abusing them?
  • Is there anyone they live with or with whom they have regular contact with that they consider supportive?
  • For chronic pain patients on opioids, consider buprenorphine OBOT preferentially to naltrexone as can also help control their pain.
  • For patients on other sedatives such as benzodiazepines or misusing alcohol, consider naltrexone as less risk of respiratory depression and proven efficacy in treating alcohol use disorders.
  • For patients with multiple substance use issues, consider referral to addiction medicine specialist’s care and/or community SUD treatment program, if available.
  • Do they have a preference such as not wanting to be on any medication that shows up on a tox screen, or is ‘habit forming’?
  • Do they want to ‘get away’ for a while from their drug use triggers, i.e., people, places and things?
  • Have they tried one of the medications before and done well, or not stayed sober with that treatment?
  • Consider referral to methadone maintenance program, i.e., an OTP.
  • Consider trial of OBOT with concurrent referral to residential, intensive outpatient, sober living, or crises housing as available in the community.
  • Help patient get medical and psychiatric conditions stable that are currently limiting the option for OBOT.

Click on each question for more information

Review Question

  1. In discussing OUD treatment options with Ms. C, she shares that her priority is to find a treatment she can fit into her busy days caring for her pre-schooler.

    What treatment would be most likely to meet her priority?

    1. Buprenorphine
    2. Methadone
    3. Naltrexone
    4. Medically managed withdrawal in a residential treatment center
Providing OUD Medication

Initiating OUD Medication Treatment

Let’s explore how to start patients on each of the three MOUD options:

Click on each medication for more information

Buprenorphine

Initiating Buprenorphine

Patients can be started on buprenorphine MOUD in office or at home, 8 to 24 hours after their last opioid use. Initial starting dose of 2 to 8mg on Day 1 is titrated over several weeks with at least weekly visits to reach a stable, steady-state dose that markedly decreases or eliminates cravings and opioid use. Therapeutic doses range from 6 to 24 mg daily.

Urine drug screening, Texas prescription drug monitoring program (PDMP) database review, treatment consent and contract review and signing are standard components of the first visit.

At home induction can be easier to incorporate into a primary care workflow than in office induction. Many patients, familiar with buprenorphine either from prior personal experience or hearing the experiences of friends, family or acquaintances, will be able to explain buprenorphine induction strategies to successfully avoid precipitated withdrawal. Other patients will need their prescribing clinician to explain the risk of precipitated withdrawal if buprenorphine is started too soon after the patient’s last opioid, how long a wait is typically needed after last opioid use for the given opioid or opioids the patient is using to start buprenorphine, the signs and symptoms of withdrawal to look for the patient to know they are in sufficient opioid withdrawal to take their first dose of buprenorphine, and how to titrate dose the first day to week of treatment.

Click here for clinician Quick Start Guide which includes sample protocols and forms as well as links to additional resources.

Since January 2023, the X-waiver requirements have been eliminated for prescribing buprenorphine to treat opioid use disorder. Any clinician with Schedule III controlled substance prescribing authority (i.e. a standard DEA certificate) can treat patients with buprenorphine using their regular DEA number and with no limits to the number of patients they may treat.

Methadone

Initiating Methadone

  • For the treatment of OUD, methadone can only legally be prescribed and dispensed by a licensed opioid treatment program (OTP).
  • Click here to find an OTP in your area.
  • Patients can expect to attend the OTP daily for directly observed dosing, and to have their dose titrated over the first several weeks of treatment to reach a stable, steady-state dose that markedly decreases or eliminates cravings and opioid use.
  • Therapeutic doses typically range from 60-120mg daily.
Naltrexone

Initiating Naltrexone

  • Patients must be opioid-free followed by a wait-period of 7-10 days before first naltrexone dose to avoid precipitated withdrawal.
  • Medically managed withdrawal in a residential or inpatient treatment center is recommended for successfully getting patients through the 7 to 10-day opioid-free wait period as ambulatory and outpatient withdrawal protocols are not well tolerated.
    Click here to find SUD treatment centers in your area.
  • Non-opioid medications for withdrawal (e.g. clonidine) can be helpful in managing a patient’s residual symptoms during the waiting period.
  • Long-acting injectable naltrexone is preferred as oral naltrexone for OUD has not been shown effective due to high rates of non-adherence, relapse and subsequent overdose.
  • Similarly, patient administered dosing is not recommended.
  • Nausea and decreased appetite are common initial side effects that typically do not recur after the first injection. Mild, local injection site irritation is not uncommon as well.
  • Patients on naltrexone are at particularly high risk of overdose if they have a slip or relapse while on therapy making overdose education and naloxone co-prescription the standard of care for these patients. Suicide risk is also elevated for the first month or two of treatment.

Continuing OUD Medication Treatment

Discontinuing OUD Medication Treatment

Opioid Overdose Prevention

Overdose Education and Naloxone Distribution (OEND) for All Patients with OUD

  • With overdose now the leading cause of accidental death, EVERY patient with OUD, whether on MOUD or not, should receive basic education about opioid overdose prevention and how to use naloxone, as well as a script for naloxone or instructions to purchase from a pharmacy via state-wide standing order.
  • All patients on chronic opioid therapy should also receive OEND.
  • OEND can also be offered to any patient who is concerned about a loved-one’s risk for opioid overdose. Bystander naloxone administration is protected in Texas.
  • Health educators, medical assistants, nurses and pharmacists can be trained to deliver overdose education. Click here for online resources.

Click on the underlined text above for more information

Opioid Overdose Prevention

Key points to emphasize when counseling patients on opioid overdose prevention include:

  • Anyone who takes an opioid is at risk for overdose not just someone with opioid use disorder.
  • Overdose can happen no matter the route of administration. Injecting opioids is riskiest, but many overdoses result from taking opioids by mouth as well.
  • Overdoses don’t always happen right after using. Overdose can occur 2 to 4 hours later depending on the opioid used and how it was taken.
  • Using alone increases the risk of overdose. Whenever possible it is better to use in the presence of others, or to let a loved one know of planned use so that they can check in with the opioid user after use, calling 911 if no response to a check in call or text.
  • It is important to call 911 when someone is having an overdose even if they are revived by naloxone, as the naloxone wears off faster than any opioid, meaning the person could go back into overdose, or even worse, use additional opioids and go into a more severe overdose, if they don’t get emergency care right away.
  • The riskiest time for overdose is right after a period of abstinence, from either their opioid of choice or MOUD, even for only a few days such as after a hospital stay, incarceration or a detox episode, as tolerance falls quickly. If resuming opioid use, ‘go low and go slow’.
  • The person most at risk for opioid overdose is a person who has previously overdosed. Taking an overdose history of any patient using opioids, whether prescribed or illegal, is important.
  • Overdose is more common when opioids are mixed with other substances that slow breathing, such as alcohol and benzodiazepines such as alprazolam.
  • Using a stimulant along with an opioid dose not cancel out the risk of overdose and won’t bring someone out of an overdose. It actually raises overdose risk as stimulants make the heart work harder, requiring more oxygen, while the opioid slows down breathing, starving the heart of that needed extra oxygen, making cardiopulmonary arrest more likely.
How to Use Naloxone

Naloxone. . .

. . . is an opioid antagonist with zero abuse liability

. . . has no effect on a person who does not have opioids in their system or who is not physically dependent on opioids

. . . has a half-life of 30-90 minutes which is shorter than that of any known opioid. Once naloxone wears off, overdose can recur making it essential to get the person emergent medical care

. . . comes in a variety of easy to administer formulations

. . . may need to be re-dosed in 3 to 5 minutes after the first dose if a person has overdosed on a potent opioid such as fentanyl


nalo
narcan
Formulations
  • Parenteral (IV/IM/SC)
    • $20-40 Generic:
      • 0.4mg/ml vials and syringes or 1 mg/ml syringes
    • $3K Evzio:
      • 0.4mg/0.4ml autoinjector
  • Intranasal
    • $70-100 Narcan nasal spray:
      • 4mg/0.1ml nasal spray
    • $70-100 Klaxxado nasal spray:
      • 8mg/0.1ml nasal spray

Review Question

  1. Ms. C would like to try buprenorphine for treating her OUD. In addition to a referral to a nearby colleague who is waivered to provide OBOT, you provide Ms. C with:

    1. Referral to a local SUD treatment center to medical manage her opioid withdrawal
    2. Naltrexone injection to tide her over until her appointment with your colleague
    3. An appointment with your practice’s therapist, telling her participating in counseling is a requirement of OBOT
    4. Education about opioid overdose prevention and a prescription for naloxone
Providing Trauma-Informed, Stigma-Free Care
Trauma-Informed Care
Introduction

Providing Trauma-Informed, Stigma-Free Care


Learning Objectives

  1. Incorporate trauma-informed care for patients including those with substance use disorders in the primary care practice.
  2. Recognize and address stigma in the primary care setting associated with persons using substances.

Completion time: About 5 minutes

Trauma, SUD and Health

Question

  1. Mr. T is a 62 yo with DM, HTN, s/p MI 3 weeks ago, presenting for post hospitalization follow up and re-engagement in care. His last visit to the practice was 3 years ago. A brief review of the EHR shows the patient engages with the practice regularly for 6 months to a year, then is ‘lost to follow-up’ for one to 3 years, re-engaging care after hospitalizations (twice for DKA, once for hypertensive crisis, prior to his recent MI). He has a remote history of cocaine use disorder in his mid-20’s to 30’s after an honorable military discharge following several tours of duty. He runs his own home repair business with his adult children.

    What in his history suggests possible trauma?

    1. Prior military service
    2. Inconsistent pattern of care
    3. History of cocaine use disorder
    4. All of the above

What is Trauma?

Adverse Childhood Experiences (ACEs)

ACEs are defined as potentially traumatic events that occur in childhood (0-17 years)

In the mid-1990s, the Centers for Disease Control and Prevention and Kaiser Permanente conducted a study to understand the relationship between childhood traumatic events and adult health. The survey asked questions about exposures to child abuse and neglect, domestic violence, drug and alcohol misuse among household members, and other traumatic stressors. (Felitti, Anda, Nordenberg et al, 1998)

ACEs are common

In the Adverse Childhood Experiences Study (or ACEs), almost two thirds reported at least one ACE while more than 1 in 5 reported THREE or more ACEs.

ACEs impact gender, ethnic and racial groups differently

Later studies have found that ACEs disproportionately affect racial and ethnic minorities. For example, 61% of Black non-Hispanic children and 51% of Hispanic children have experienced at least one ACE compared to 40% of White non-Hispanic children.

ACEs are costly

As the number of ACEs increase, the risk for health problems later in life also increase, including alcohol use disorder, obesity, COPD, depression, liver disease, cancer, stroke, and sexually transmitted infections (to name a few), amounting to hundreds of billions of dollars each year in economic and social costs.


The Truth About Aces

What is the Relationship of ACEs to Substance Use and Related Behavioral Health Problems?

Early initiation of drinking and illicit drug use

  • ACEs, such as childhood abuse (physical, sexual, psychological) and parental substance misuse, are associated with a higher risk of developing a mental and/or substance use disorder later in life. (Choi, DiNitto, Marti, & Choi, 2017).
  • Prevalence ratios for current and ever smoking have been shown to increase as ACE scores increase. (Ford et al., 2011).
  • For every additional ACE score, the rate of number of prescription drugs used increases by 62%. (Forster, Gower, Borowsky, & McMorris, 2017).
  • ACEs in any category increase the risk of attempted suicide by 2- to 5-fold throughout a person’s lifespan (Dube et al., 2001), and individuals who reported 6 or more ACEs had over 24-times increased odds of attempting suicide (Merrick et al., 2017).

Lifetime depressive episodes, sleep disturbances, high-risk sexual behaviors all show a graded, dose response effect with ACEs

SAMHSA, Center for the Application of Prevention Technologies, June 2018

Click on items in blue text for more information

Review Question

  1. Ms. A is a 31 yo with anxiety and insomnia presenting with recurrent UTI signs and symptoms. This is her 3rd urgent/walk in visit in the last 4 months for the same complaints, which were previously treated empirically with SMP/TMX then ciprofloxacin. On reviewing her history in the EHR, you notice Ms. A’s last counseling note from the therapist recently integrated into the practice’s care team, mentions a history of childhood sexual abuse and current emotionally abusive partner, as well as ongoing cannabis use since the patient’s mid teens. Also noted is a strong and supportive relationship with her older sister. She is also overdue a well woman exam. As you are taking the patient’s HPI with her today for this urgent care visit, she denies fever, chills, nausea and vomiting, but declines to answer questions about recent sexual activity, stating that she knows to void after intercourse and that she has no abnormal vaginal discharge. During the physical exam she agrees to palpation of her abdomen including suprapubic area, which is tender, and back which reveals no CVAT. She adamantly refuses a GYN exam now or scheduling a future well woman visit. She is reluctant to provide a urine specimen as she is worried you will send it for a urine drug screen as well, the results of which could jeopardize her job.

    Which of the following is NOT consistent with providing trauma-informed care to Ms. A?

    1. Send urine specimen, which she is willing to give when reassured that you are only requesting tests needed to check for infection.
    2. Ask Ms. A if she’d reconsider scheduling her needed well woman exam if her sister could be with her to provide support.
    3. Tell Ms. A firmly but kindly that it is unethical for you to continue to treat her symptoms with antibiotics without needed tests and exams, so she should look for another practice/provider if she won’t comply.
    4. Affirm Ms. A’s commitment to her health in seeking care for her current problem and in working with the therapist.
Trauma-Informed Care
Trauma-Informed Care

Trauma-Informed Care: Avoiding Re-Traumatization

An essential goal of trauma-informed care is to avoid re-traumatization. Respecting patient autonomy and supporting patient empowerment are key. You and other members of the patient’s care team can:

Respect patient autonomy through

Ensuring the patient retains control of their narrative and body by
  • supporting a patient’s decision to refuse to answer a question, complete a form or submit to any part of the physical exam
  • asking permission throughout the exam or procedure when evaluation, diagnosis or treatment involves physical touch

Support patient empowerment through

Encouraging the patient to be a full participant in their healthcare by
  • collaborating with the patient on their treatment plan
  • affirming the patient’s strengths and working to enhance their sense of self-efficacy

Providing Trauma-Informed Care

A simple, yet powerful way to look at trauma-informed care is to consider shifting the paradigm from “what is wrong with you?” to “what happened to you?”

To provide effective care we need to understand the life situations that may be contributing to the patient’s current problems.

Many current problems faced by the persons we serve may be related to traumatic life experiences.

People who have experienced traumatic life events are often very sensitive to situations that remind them of the people, places or things involved in their traumatic events.

These reminders, also known as triggers, may cause a person to relive the trauma and view the healthcare setting/organization as a source of distress rather than a place of healing and wellness.

Trauma-informed care is most effective when implemented practice-wide, not patient or provider specific.


SAMHSA’s Six Key Principles

Trauma-informed Clinical Practices:

  • Involve patients in the treatment process
  • Train staff in trauma-specific treatment approaches
  • Screen for trauma. At a minimum, ask patients routinely about whether they have experienced any trauma
  • Click here for a short, evidence-based PTSD screening instrument that can be used in primary care
  • Engage referral sources and partnering organizations to learn how they respond to the needs of patients who have experience trauma
Evidence-based PTSD screening instrument
PTSD screening instrument

Infographic-Trauma-Informed Care

Review Question

  1. Mrs. C is a seventy-six-year-old longstanding patient of yours with well controlled hypertension presenting for routine follow up and a flu vaccine. Recently the practice has implemented a PTSD screen as part of the intake process, and the medical assistant has flagged this patient’s screen as positive in the electronic health record. In discussing the positive screen with Mrs. C, you are surprised to hear about a traumatic event now almost two decades past, that has had a long- lasting impact on her sleep and independence, which she has not felt was something to bring up at a medical visit. The incident happened at a gas station one evening as she was traveling between Houston and McAllen which she often did for work before retirement. She was assaulted and robbed at gunpoint and since then has had sleep issues and has her spouse do the refueling of all their vehicles as she panics pulling into gas stations. As her spouse is a few years older than her with several chronic health conditions, Mrs. C is worried about what will happen if he passes first in terms of her independence and mobility. She is grateful, as are you, for the opportunity to address her concerns this visit.

    Which of the following statements does NOT represent an empathetic, validating response to Mrs. C’s trauma disclosure?

    1. “I’m sorry that that happened to you; no one has the right to assault another person.”
    2. “I’m surprised you’re not over that by now. That’s definitely a problem.”
    3. “No one should have to face such an upsetting and scary situation.”
    4. “We know that there is a direct relationship between this type of experience and a person’s physical health; have you ever had a chance to explore this?”
Stigma and SUD

For Integrated Practices: Seeking Safety

Developed in 2002, Seeking Safety is an evidence-based, counseling intervention that addresses co-occurring substance use disorders and PTSD. It was first developed for women then expanded to men and can be delivered individually or in a group setting:

  • It is 25 sessions over three months, with sessions held twice weekly
  • The syllabus is highly structured and manualized
      Includes check-in, quotation, handouts, and check out
  • The intervention is present-oriented, i.e., what can be done now to improve safety
  • Sessions focus on:

    1. prioritizing safety
    2. integrating trauma and substance use
    3. rebuilding a sense of hope for the future
    4. building cognitive, behavioral, interpersonal, and case management skill sets
    5. refining clinicians’ attention to processes

 Empowerment is key

Najavits, L.M., (2002) Seeking Safety A Treatment Manual for PTSD and Substance Abuse. New York: Guilford Press

Review Question

  1. Mr. P is a 44-year-old new patient presenting with chronic back pain from an injury 2 years ago. As you enter the room and greet the patient you sense they’re on edge and ask if everything is ok so far this visit. The patient tersely relates overhearing front desk staff saying he is ‘drug seeking’ when letting the medical assistant know Mr. P has completed the check in process and is ready to be roomed. He also felt judged by the medical assistant after he answered yes to smoking cigarettes and drinking alcohol on the standard substance use screen the practice uses, noticing her tone changing from welcoming and conversational to cold and curt for the rest of the rooming process. You acknowledge the patient’s concerns, and he tells you he was thinking of just walking out without being seen, but really wanted to meet you as you are taking care of one of his friends who also has chronic pain. You’ve significantly helped the friend get a better handle on the pain without resorting to opioids. Mr. P has sought care from several other providers, who offered opioids when short trials of non-narcotic pain relievers didn’t help, but he is adamantly against taking opioids since his twin died of an opioid overdose 4 years ago, when the patient found him unresponsive during a camping trip, having not realized his brother had relapsed.

    What experiences did this patient have this visit that were stigmatizing and what were trauma-informed?

    1. Stigmatizing: drug seeking labelling by front desk staff
    2. Stigmatizing: judgmental tone of medical assistant
    3. Trauma-Informed: validation by provider seeking to understand and acknowledge patient concerns
    4. All of the above

Stigma: A Barrier to Care

  • As clinicians, we are reminded almost daily of the impact of stigma on the health and wellbeing of individuals. Through a focus on public education, we have moved the needle somewhat when it comes to stigma related to mental health conditions such as depression and anxiety. Unfortunately, less progress has been made regarding substance use disorders.
  • People with substance use disorders continue to be blamed for their disease and often internalize that stigma. They feel tremendous amounts of shame and may refuse to seek treatment as a result. Stigma can significantly inhibit individual help-seeking behaviors. Self-stigma is also associated with low self-efficacy and may hinder accurate self-disclosure about use.
  • Unconscious bias about who may or may not be at risk for substance use and use disorders can prevent healthcare professionals from asking about alcohol or drug use.
  • Stigmatizing attitudes from clinicians can lead to under-treatment of patients with substance use disorders.

Addiction is not a choice
Massachusetts Department of Public Health

Stigma and Medications for Substance Use Disorders (MSUD)

  • Stigma is one of the biggest barriers to use of medications in treating SUD, and goes hand in hand with access to limit effective treatment of these life-threatening disorders
  • There remains a large discrepancy between prevalence rates of SUD and use of medications in treating SUD (MSUD) a result. Stigma can significantly inhibit individual help-seeking behaviors. Self-stigma is also associated with low self-efficacy and may hinder accurate self-disclosure about use.
  • Common myths:

    1. MSUD substitutes one addiction for another
    2. MSUD is only a short-term treatment
    3. MSUD is only for patients with severe illness
    4. MSUD won’t be covered by most insurances
  • Patients taking medication for a SUD do not meet some 12-step based programs’ definitions of abstinence because of their use of opioid agonist or partial agonist medications. They may be excluded from these groups and programs or find they are only accepted if they conceal their treatment modality. Additionally, even when they are attending 12-step groups, they may be criticized as having “traded one drug for another” if they reveal that they are seeking treatment with buprenorphine or methadone. However, this is not always the case, and many AA and NA members understand the role of medications for treating SUDs.

The Role of the Primary Care Practice & Provider in Addressing Stigma

One of the most affirming and easiest changes that can be made is to change the language we use when talking about substance use disorders.

  • Person-first language maintains the integrity of individuals as whole human beings—by removing language that equates people to their condition or has negative connotations. For example, “person with a substance use disorder” has a neutral tone and distinguishes the person from his or her diagnosis.
  • Some of you may have also encountered patients who identify themselves as addicts or use some of the language that we are recommending to change. That’s okay. The patient is free to self-identify in any way but as healthcare professionals, we can encourage adoption of language that can destigmatize substance use disorders.
  • NIDA also recommends that “substance use” be used to describe all substances, including alcohol and other drugs, and that clinicians refer to severity specifiers – mild, moderate, severe – to indicate the severity of the SUD. This language also supports documentation of accurate clinical assessment and development of effective treatment plans.
  • When talking about treatment plans with people with SUD and their loved ones, be sure to use evidence-based language instead of referring to treatment as an intervention. It is a misconception that medications merely “substitute” one drug or “one addiction” for another.
  • Avoid terms such as addict, abuse, clean/dirty, addicted baby, medication assisted treatment which have been shown to increase stigma. Click here for more more information.

Other ways to decrease stigma:

  • Increase availability and access to medications for SUD (MSUD) in the primary care setting.
  • Promote awareness of SUD as a chronic, relapsing and treatable brain disease.
  • Connect patients with supportive recovery community, including peers.
Your Words Matter
National Institute on Drug Abuse (NIDA)
Post-Training Survey and CME/CEU Certificate
Post-Training Survey & CME/CEU Certificate

Post-Training Survey and CME/CEU Certificate

Instructions: Complete all the modules then take the post-training survey to claim CME/CEU

Please watch the entire video and then take the post-training survey to claim CME/CEU

To receive your CME/CEU Certificate and $20 incentive, please complete the Post-Training Survey.

When completing the Post-Training Survey, use the same identifier details provided during registration and the Pre-Training Survey:

  • First Initial of Middle Name: fi
  • Month of Birth: mob
  • First Letter of Mother's First Name: fim
  • Clinic Location: loc